KCNA4
Encyclopedia
Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein
that in humans is encoded by the KCNA4 gene
. It contributes to the cardiac transient outward potassium current
(Ito1), the main contributing current to the repolarizing
phase 1 of the cardiac action potential.
with DLG4
, KCNA2
and DLG1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the KCNA4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. It contributes to the cardiac transient outward potassium current
Cardiac transient outward potassium current
The cardiac transient outward potassium current is the main contributing current to the repolarizing phase 1 of the cardiac action potential, and results from movement of potassium ions from the intracellular to the extracellular space...
(Ito1), the main contributing current to the repolarizing
Repolarization
In neuroscience, repolarization refers to the change in membrane potential that returns the membrane potential to a negative value after the depolarization phase of an action potential has just previously changed the membrane potential to a positive value. Repolarization results from the movement...
phase 1 of the cardiac action potential.
Description
Interactions
KCNA4 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with DLG4
DLG4
PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene....
, KCNA2
KCNA2
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene.-Interactions:KCNA2 has been shown to interact with KCNA4, DLG4, PTPRA, KCNAB2, RHOA and Cortactin....
and DLG1
DLG1
Disks large homolog 1 , also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene....
.