Jean Nageotte
Encyclopedia
Jean Nageotte was a French neuroanatomist
Neuroanatomy
Neuroanatomy is the study of the anatomy and organization of the nervous system. In contrast to animals with radial symmetry, whose nervous system consists of a distributed network of cells, animals with bilateral symmetry have segregated, defined nervous systems, and thus we can begin to speak of...

 born in Dijon
Dijon
Dijon is a city in eastern France, the capital of the Côte-d'Or département and of the Burgundy region.Dijon is the historical capital of the region of Burgundy. Population : 151,576 within the city limits; 250,516 for the greater Dijon area....

. He obtained his medical degree in Paris
Paris
Paris is the capital and largest city in France, situated on the river Seine, in northern France, at the heart of the Île-de-France region...

 in 1893, and afterwards was associated with the Hôpital Bicêtre and Salpêtrière. He succeeded Louis-Antoine Ranvier
Louis-Antoine Ranvier
Louis-Antoine Ranvier was a French physician, pathologist, anatomist and histologist, who discovered nodes of Ranvier, regularly spaced constrictions of the myelin sheath, occurying at varying intervals along the length of a nerve fiber.Ranvier was born and studied medicine at Lyon, graduating in...

 (1835–1922) in what then became the chair of comparative histology
Histology
Histology is the study of the microscopic anatomy of cells and tissues of plants and animals. It is performed by examining cells and tissues commonly by sectioning and staining; followed by examination under a light microscope or electron microscope...

 at the Collège de France
Collège de France
The Collège de France is a higher education and research establishment located in Paris, France, in the 5th arrondissement, or Latin Quarter, across the street from the historical campus of La Sorbonne at the intersection of Rue Saint-Jacques and Rue des Écoles...

.

Nageotte specialized in anatomical research of the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...

, and in his work stressed the importance of microscopic anatomy. He performed research of nerve fiber
Nerve fiber
A nerve fiber is a threadlike extension of a nerve cell and consists of an axon and myelin sheath in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system , myelin...

s and the myelin sheath, and conducted studies involving connective tissue
Connective tissue
"Connective tissue" is a fibrous tissue. It is one of the four traditional classes of tissues . Connective Tissue is found throughout the body.In fact the whole framework of the skeleton and the different specialized connective tissues from the crown of the head to the toes determine the form of...

. He provided a description of boutons terminaux (terminal buttons) of spinal nerves, and did extensive work with nerve grafting
Medical grafting
Grafting refers to a surgical procedure to move tissue from one site to another on the body, or from another person, without bringing its own blood supply with it. Instead, a new blood supply grows in after it is placed. A similar technique where tissue is transferred with the blood supply intact...

. In addition he investigated tabes dorsalis
Tabes dorsalis
Tabes dorsalis is a slow degeneration of the sensory neurons that carry afferent information. The degenerating nerves are in the dorsal columns of the spinal cord and carry information that help maintain a person's sense of position , vibration, and discriminative touch.-Cause:Tabes dorsalis is...

, and with Joseph Babinski
Joseph Babinski
Joseph Jules François Félix Babinski was a French neurologist of Polish descent. He is best known for his 1896 description of the Babinski sign, a pathological plantar reflex indicative of corticospinal tract damage....

 (1857–1932), the Babinski-Nageotte syndrome
Babinski-Nageotte syndrome
Babinski-Nageotte syndrome, sometimes called Babinski syndrome, is an alternating brainstem syndrome. It occurs when there is damage to the dorsolateral or posterior lateral medulla oblongata...

 was described. This syndrome is a complex of symptoms associated with medullary
Medulla oblongata
The medulla oblongata is the lower half of the brainstem. In discussions of neurology and similar contexts where no ambiguity will result, it is often referred to as simply the medulla...

 lesions. He documented this disorder in a treatise called Hémiasynergie, latéropulsion et miosis bulbaire. Also with Babinski, he co-wrote a book on cerebrospinal fluid
Cerebrospinal fluid
Cerebrospinal fluid , Liquor cerebrospinalis, is a clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord...

.

Other eponyms associated with Jean Nageotte:
  • Nageotte cells: mononuclear cells found in the cerebrospinal fluid; 1 or 2 Nageotte cells per cubic milimeter are typically found in healthy individuals, but larger numbers of these cells are an indication of disease.
  • Nageotte's radicular nerve: Nageotte placed the initial lesion of tabes dorsalis
    Tabes dorsalis
    Tabes dorsalis is a slow degeneration of the sensory neurons that carry afferent information. The degenerating nerves are in the dorsal columns of the spinal cord and carry information that help maintain a person's sense of position , vibration, and discriminative touch.-Cause:Tabes dorsalis is...

     in the root component of the radicular nerve.

Written works

  • Tabès et paralysie générale (Tabes and general paralysis), Paris, Steinheil, 1893.
  • Contribution à l’étude du cytodiagnostic du liquide céphalo-rachidien dans les affections nerveuses (Contribution to the study of cytodiagnostics of cerebrospinal fluid in nervous disorders) Tours, Maretheux, 1901.
  • Pathogénie du tabes dorsal (Pathogenesis
    Pathogenesis
    The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent...

     of tabes dorsalis) Paris, Naud, 1903.
  • La Structure fine du système nerveux (The delicate structure of the nervous system), Paris, Maloine, 1905.
  • L’Organisation de la matière dans ses rapports avec la vie Paris, 1922.
  • Morphologie des gels lipoïdes, myéline, cristaux liquides, vacuoles (Morphology of lipoidal gel, myelin, liquid crystals, vacuole
    Vacuole
    A vacuole is a membrane-bound organelle which is present in all plant and fungal cells and some protist, animal and bacterial cells. Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic molecules including enzymes in solution, though in certain...

    s), Paris, Hermann, 1937
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