JWH-203
Encyclopedia
JWH-203 is an analgesic
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
with approximately equal affinity at both the CB1 and CB2
receptors, having a Ki
of 8.0nM at CB1 and 7.0nM at CB2. Similar to the related 2'-methoxy
compound JWH-250
, the 2'-bromo compound JWH-249
, and the 2'-methyl compound JWH-251
, JWH-203 has a phenylacetyl
group in place of the naphthoyl ring used in most aminoalkylindole
cannabinoid compounds, and is the most potent compound found in the phenylacetyl group. It was originally discovered by, and named after, Dr. John W. Huffman
, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends.
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
with approximately equal affinity at both the CB1 and CB2
Cannabinoid receptor 2 (macrophage)
Cannabinoid receptor 2 , also known as CB2 or CNR2, is a G protein-coupled receptor from the cannabinoid receptor family, which in humans is encoded by the CNR2 gene...
receptors, having a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 8.0nM at CB1 and 7.0nM at CB2. Similar to the related 2'-methoxy
Methoxy
In chemistry , methoxy refers to the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula O–CH3.The word is used in organic nomenclature usually to describe an ether...
compound JWH-250
JWH-250
JWH-250 or is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2...
, the 2'-bromo compound JWH-249
JWH-249
JWH-249 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB1 with a Ki of 8.4nM ± 1.8 and 20nM ± 2 at CB2...
, and the 2'-methyl compound JWH-251
JWH-251
JWH-251 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 5x selectivity for CB1 with a Ki of 29nM and 146nM at CB2...
, JWH-203 has a phenylacetyl
Acetyl
In organic chemistry, acetyl is a functional group, the acyl with chemical formula COCH3. It is sometimes represented by the symbol Ac . The acetyl group contains a methyl group single-bonded to a carbonyl...
group in place of the naphthoyl ring used in most aminoalkylindole
Indole
Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. Indole is a popular component of fragrances and the precursor to many pharmaceuticals. Compounds that contain an...
cannabinoid compounds, and is the most potent compound found in the phenylacetyl group. It was originally discovered by, and named after, Dr. John W. Huffman
John W. Huffman
John William Huffman is a professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids, including JWH-007, JWH-015, JWH-018, JWH-019, JWH-030, JWH-051, JWH-073, JWH-081, JWH-122, JWH-133, JWH-147, JWH-171, JWH-182, JWH-203, JWH-210, JWH-250, JWH-307,...
, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends.