JTE 7-31
Encyclopedia
JTE 7-31 is a selective cannabinoid receptor
agonist invented by Japan Tobacco
. It is a reasonably highly selective CB2 agonist, but still retains appreciable affinity at CB1, with a Ki
of 0.088nM at CB2 vs 11nM at CB1.
Cannabinoid receptor
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...
agonist invented by Japan Tobacco
Japan Tobacco
, abbreviated JT, is a cigarette manufacturing company. It is part of the Nikkei 225 index. In 2009 the company was listed at number 312 on the Fortune 500 list. The company is headquartered in Toranomon, Minato, Tokyo. The international headquarters are in Geneva, Switzerland.-History:The company...
. It is a reasonably highly selective CB2 agonist, but still retains appreciable affinity at CB1, with a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 0.088nM at CB2 vs 11nM at CB1.
See also
- A-834,735A-834,735A-834,735 is a drug developed by Abbott Laboratories which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2...
- JTE-907JTE-907JTE-907 is a drug used in scientific research which acts as a selective CB2 inverse agonist. It has antiinflammatory effects in animal studies, thought to be mediated by an interaction between the CB2 receptor and IgE....
- MDA-19MDA-19MDA-19 is a drug which acts as a potent and selective agonist for the cannabinoid receptor CB2, with reasonable selectivity over the psychoactive CB1 receptor, though with some variation between species...
- N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamideN-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide7-methoxy-1--N--1H-indole-3-carboxamide is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors...