Ionotropic effect
Encyclopedia
An ionotropic effect is a special kind of effect of a hormone
on its target. The hormone activates or deactivates ionotropic receptors (ligand-gated ion channels). The effect can be either positive or negative, whether the effect is a depolarization or a hyperpolarization respectively.
s on this tissue. The result is an increased cardiac output
.
Hormone
A hormone is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from one...
on its target. The hormone activates or deactivates ionotropic receptors (ligand-gated ion channels). The effect can be either positive or negative, whether the effect is a depolarization or a hyperpolarization respectively.
Examples
Noradrenaline (aka. Norepinephrine) has a positive ionotropic effect on heart muscle, when binding to beta-1 adrenergic receptorBeta-1 adrenergic receptor
The beta-1 adrenergic receptor , also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it...
s on this tissue. The result is an increased cardiac output
Cardiac output
Cardiac output is the volume of blood being pumped by the heart, in particular by a left or right ventricle in the time interval of one minute. CO may be measured in many ways, for example dm3/min...
.