Intravascular lymphoma
Encyclopedia
Intravascular lymphoma, also referred to as angiotropic large cell lymphoma,, intralymphatic lymphomatosis, intravascular lymphomatosis,, and "Malignant angioendotheliomatosis", is a condition that may present with variable symptoms, including
various cutaneous morphologies (that are often very subtle and non-specific), and CNS symptoms.
Most intravascular lymphomas are of the B-cell lineage.
Presentations may include non-specific cutaneous lesions, and/or CNS involvement.
The diagnosis is established by the examination of tissue
under the microscope
(i.e. biopsy
or autopsy
). Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal lymphocyte, and typically have a prominent nucleolus
.
.
various cutaneous morphologies (that are often very subtle and non-specific), and CNS symptoms.
Most intravascular lymphomas are of the B-cell lineage.
Diagnosis
Intravascular lymphoma is a condition that may present with non-specific symptoms and, thus, may be difficult to diagnose in a timely manner.Presentations may include non-specific cutaneous lesions, and/or CNS involvement.
The diagnosis is established by the examination of tissue
Tissue (biology)
Tissue is a cellular organizational level intermediate between cells and a complete organism. A tissue is an ensemble of cells, not necessarily identical, but from the same origin, that together carry out a specific function. These are called tissues because of their identical functioning...
under the microscope
Microscope
A microscope is an instrument used to see objects that are too small for the naked eye. The science of investigating small objects using such an instrument is called microscopy...
(i.e. biopsy
Biopsy
A biopsy is a medical test involving sampling of cells or tissues for examination. It is the medical removal of tissue from a living subject to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically...
or autopsy
Autopsy
An autopsy—also known as a post-mortem examination, necropsy , autopsia cadaverum, or obduction—is a highly specialized surgical procedure that consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present...
). Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal lymphocyte, and typically have a prominent nucleolus
Nucleolus
The nucleolus is a non-membrane bound structure composed of proteins and nucleic acids found within the nucleus. Ribosomal RNA is transcribed and assembled within the nucleolus...
.
Classification
- Intravascular large B-cell lymphomaIntravascular large B-cell lymphomaIntravascular large B-cell lymphoma, abbreviated ILBCL and also referred to as angiotropic large-cell lymphoma, intralymphatic lymphomatosis, intravascular lymphomatosis,, and, less specifically intravascular lymphoma.-Diagnosis:...
(ILBCL) - Intravascular anaplastic large cell lymphoma
History
It used to be known as malignant angioendotheliomatosis, as it was once thought to arise from the endotheliumEndothelium
The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart...
.