Interleukin 8 receptor, alpha is a chemokine receptor

Chemokine receptor

Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. There have been 19 distinct chemokine receptors described in mammals...

. IL8RA is its human gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. IL8RA has also been designated CD181 (cluster of differentiation

Cluster of differentiation

The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells...

 181), and CXCR1. CXCR1 is now the IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name.

Clinical significance

Blocking CXCR1 (e.g. with repertaxin) inhibits some human breast cancer stem cells (in vitro and in mice).

See also

• Interleukin 8 receptor, beta
  Interleukin 8 receptor, beta
  Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.-Function:...
  
  
• Interleukin-8 receptor
  Interleukin-8 receptor
  Interleukin-8 receptor is an interleukin receptor of the chemokine receptor type....
  
  
• Interleukin 8
  Interleukin 8
  Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies...
  
  
• Interleukin
  Interleukin
  Interleukins are a group of cytokines that were first seen to be expressed by white blood cells . The term interleukin derives from "as a means of communication", and "deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes"...
  
  
• Interleukin receptor
  Interleukin receptor
  -Types:There are two main families of Interleukin receptors, type 1 and type 2 cytokine receptors.-Other:*Interleukin-1 receptor and interleukin-18 receptor belong to the immunoglobulin superfamily....
  
  

Interactions

Interleukin 8 receptor, alpha has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with GNAI2

GNAI2

Guanine nucleotide-binding protein G, alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.-Interactions:GNAI2 has been shown to interact with GPSM2, RIC8A, Interleukin 8 receptor, alpha, EYA2, RGS5 and MDFI.-Further reading:...

.

Further_reading