Interferon gamma receptor 2 also known as IFNGR2 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the IFNGR2 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor

Interferon-gamma receptor

The interferon-gamma receptor is a receptor which binds interferon-γ, the sole member of interferon type II.- Structure and function :...

. Human interferon-gamma receptor is a heterodimer of IFNGR1

Interferon gamma receptor 1

Interferon gamma receptor 1 also known as CD119 , is a human gene.- Function :...

 and IFNGR2.

Clinical significance

Defects in IFNGR2 are a cause of autosomal recessive mendelian susceptibility to mycobacterial

Mycobacterium

Mycobacterium is a genus of Actinobacteria, given its own family, the Mycobacteriaceae. The genus includes pathogens known to cause serious diseases in mammals, including tuberculosis and leprosy...

disease (MSMD), also known as familial disseminated atypical mycobacterial infection.