Integrative neuroscience
Encyclopedia
Integrative neuroscience sculptures a theoretical neuroscience with a
mathematical neuroscience that is different from computational neuroscience
(Poznanski). Its aim is to present studies of the functional organization of particular brain systems across hierarchical levels through integrative approaches leading to species-typical behaviors under normal and pathological states . It epitomizes top-down and bottom-up phenomenological models, as well as theoretical and philosophical foundations for explicit hierarchical and functional integration in the brain.
This integrative approach focuses on the brain as an adaptive system.
It is concerned with how all the components of the brain are coordinated, and the principles that guide this coordination. A key organizing principle is the importance of our need to avoid potential danger or threat, and maximize safety and reward. In humans, we see this principle operating in regard to responses driven by external information, as well as internally-generated goals. As such, Integrative Neuroscience aims for a unified understanding of brain function across timescales. It draws on information from different measurement sources (including both brain and body measures) to test these unifying principles.
A concrete exemplar of the value of large-scale data sharing has been provided by the Human Brain Project.
The importance of large-scale integration of brain information for new approaches to medicine has been recognized . Rather than relying mainly on symptom information, a combination of brain and gene information may ultimately be required for understanding what treatment is best suited to which individual person.
It provides a framework for linking the great diversity of specializations within contemporary neuroscience
, including
This diversity is inevitable, yet has arguably created a void: neglect of the primary role of the nervous system in enabling the animal to survive and prosper. Integrative neuroscience aims to fill this perceived void.
.
mathematical neuroscience that is different from computational neuroscience
(Poznanski). Its aim is to present studies of the functional organization of particular brain systems across hierarchical levels through integrative approaches leading to species-typical behaviors under normal and pathological states . It epitomizes top-down and bottom-up phenomenological models, as well as theoretical and philosophical foundations for explicit hierarchical and functional integration in the brain.
This integrative approach focuses on the brain as an adaptive system.
It is concerned with how all the components of the brain are coordinated, and the principles that guide this coordination. A key organizing principle is the importance of our need to avoid potential danger or threat, and maximize safety and reward. In humans, we see this principle operating in regard to responses driven by external information, as well as internally-generated goals. As such, Integrative Neuroscience aims for a unified understanding of brain function across timescales. It draws on information from different measurement sources (including both brain and body measures) to test these unifying principles.
Motivation
Since the ‘decade of the brain’ there has been an explosion of insights into the brain and their application in most areas of medicine. With this explosion, the need for integration of data across studies, modalities and levels of understanding is increasingly recognized.A concrete exemplar of the value of large-scale data sharing has been provided by the Human Brain Project.
The importance of large-scale integration of brain information for new approaches to medicine has been recognized . Rather than relying mainly on symptom information, a combination of brain and gene information may ultimately be required for understanding what treatment is best suited to which individual person.
It provides a framework for linking the great diversity of specializations within contemporary neuroscience
Neuroscience
Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience has been seen as a branch of biology. However, it is currently an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics,...
, including
- Molecular neuroscienceMolecular neuroscienceMolecular neuroscience is a branch of neuroscience that examines the biology of the nervous system with molecular biology, molecular genetics, protein chemistry and related methodologies. Molecular biology studies how deoxyribonucleic acid forms ribonucleic acid which makes protein...
— genetic and cellular aspects of brain function - Neuroanatomy — connections, networks, neurotransmitter systems
- Behavioral neuroscienceBehavioral neuroscienceBehavioral neuroscience, also known as biological psychology, biopsychology, or psychobiology is the application of the principles of biology , to the study of physiological, genetic, and developmental mechanisms of behavior in human and non-human animals...
— the overt consequences of neural activity - Systems neuroscienceSystems neuroscienceSystems neuroscience is a subdiscipline of neuroscience and systems biology that studies the function of neural circuits and systems. It is an umbrella term, encompassing a number of areas of study concerned with how nerve cells behave when connected together to form neural networks...
— description of sensory and motors systems - Developmental neuroscience — structural and functional changes during maturation
- Cognitive neuroscienceCognitive neuroscienceCognitive neuroscience is an academic field concerned with the scientific study of biological substrates underlying cognition, with a specific focus on the neural substrates of mental processes. It addresses the questions of how psychological/cognitive functions are produced by the brain...
— channels and stages of sensory processing, including memory - Mathematical neuroscience — quantitative simulation and emulation of neuronal and brain function
- Clinical observations — evidence that can be gleaned from brain dysfunction
This diversity is inevitable, yet has arguably created a void: neglect of the primary role of the nervous system in enabling the animal to survive and prosper. Integrative neuroscience aims to fill this perceived void.
Evolutionary basis
Integrative neuroscience draws on the important context of our evolutionary history Charles DarwinCharles Darwin
Charles Robert Darwin FRS was an English naturalist. He established that all species of life have descended over time from common ancestry, and proposed the scientific theory that this branching pattern of evolution resulted from a process that he called natural selection.He published his theory...
.