Integrated DNA Technologies
Encyclopedia
Integrated DNA Technologies, Inc. (IDT), headquartered in Coralville, Iowa
, is the largest supplier of custom nucleic acids in the U.S., serving the areas of academic research, biotechnology, clinical diagnostics, and pharmaceutical development. IDT's primary business is the manufacturing of custom DNA
and RNA
oligonucleotides (oligos) for research applications.
Joseph Walder, M.D., Ph.D. (Northwestern University
), founded Integrated DNA Technologies, Inc. in 1987 through a partnership with Baxter Healthcare Corporation at the University of Iowa
Technology Innovation Center business incubator. In its first 10 years, the company grew from a start-up with 10 synthesizing machines to one with more than 500, shipping an average 36,000 custom oligos per day to its over 77,000 customers worldwide, enabling them to test for genetic diseases, discover new drugs, and develop new treatment models tailored to the specific needs of individual patients.
applications, e.g. polymerase chain reaction
(PCR), molecular beacons, microarrays, mutagenesis, RNAi
, antisense and de novo gene construction. Published bioinformatics
algorithms can predict biophysical properties of oligonucleotides from their sequence and estimate performance of oligonucleotides in specific assays both singly and together with other sequences. IDT's SciTools is a free online suite of computational software tools that enable molecular biologists to design, evaluate and make informed decisions about the properties of nucleic acid sequences. Instructions and help to each software tool can be found at the top of web input forms. The code is regularly updated when more accurate models and algorithms are published.
IDT earned its ISO 13485
:2003 certification for its Quality Management System in 2008.
Coralville, Iowa
Coralville is a city in Johnson County, Iowa, United States. It is a suburb of Iowa City and part of the Iowa City Metropolitan Statistical Area...
, is the largest supplier of custom nucleic acids in the U.S., serving the areas of academic research, biotechnology, clinical diagnostics, and pharmaceutical development. IDT's primary business is the manufacturing of custom DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
and RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
oligonucleotides (oligos) for research applications.
Joseph Walder, M.D., Ph.D. (Northwestern University
Northwestern University
Northwestern University is a private research university in Evanston and Chicago, Illinois, USA. Northwestern has eleven undergraduate, graduate, and professional schools offering 124 undergraduate degrees and 145 graduate and professional degrees....
), founded Integrated DNA Technologies, Inc. in 1987 through a partnership with Baxter Healthcare Corporation at the University of Iowa
University of Iowa
The University of Iowa is a public state-supported research university located in Iowa City, Iowa, United States. It is the oldest public university in the state. The university is organized into eleven colleges granting undergraduate, graduate, and professional degrees...
Technology Innovation Center business incubator. In its first 10 years, the company grew from a start-up with 10 synthesizing machines to one with more than 500, shipping an average 36,000 custom oligos per day to its over 77,000 customers worldwide, enabling them to test for genetic diseases, discover new drugs, and develop new treatment models tailored to the specific needs of individual patients.
Mission
IDT's primary mission is to improve nucleic acid synthesis technology and develop new applications for the use of DNA and RNA-based compounds. IDT's advanced synthesis group combines expertise in chemistry, molecular biology and engineering to produce and purify complex nucleic acids of all kinds.SciTools http://www.idtdna.com/Scitools/Scitools.aspx
Synthetic oligonucleotides are widely employed in various molecular biologyMolecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
applications, e.g. polymerase chain reaction
Polymerase chain reaction
The polymerase chain reaction is a scientific technique in molecular biology to amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence....
(PCR), molecular beacons, microarrays, mutagenesis, RNAi
RNAI
RNAI is a non-coding RNA that is an antisense repressor of the replication of some E. coli plasmids, including ColE1. Plasmid replication is usually initiated by RNAII, which acts as a primer by binding to its template DNA. The complementary RNAI binds RNAII prohibiting it from its initiation role...
, antisense and de novo gene construction. Published bioinformatics
Bioinformatics
Bioinformatics is the application of computer science and information technology to the field of biology and medicine. Bioinformatics deals with algorithms, databases and information systems, web technologies, artificial intelligence and soft computing, information and computation theory, software...
algorithms can predict biophysical properties of oligonucleotides from their sequence and estimate performance of oligonucleotides in specific assays both singly and together with other sequences. IDT's SciTools is a free online suite of computational software tools that enable molecular biologists to design, evaluate and make informed decisions about the properties of nucleic acid sequences. Instructions and help to each software tool can be found at the top of web input forms. The code is regularly updated when more accurate models and algorithms are published.
Major Product Areas http://www.idtdna.com/catalog/catalog.aspx
| Custom Oligonucleotide Synthesis & Purification | Oligonucleotide Modifications |
| cGMP Manufacturing | Gene Expression Assays |
| Gene Silencing Products | Molecular Biology Reagents |
| Fluorescence-Based Applications | ReadyMade Primers and Products |
| Synthetic Biology | Next-Generation Sequencing Products |
Associations
IDT is a member of the Technology Association of Iowa.Certifications
IDT earned its ISO 9001:2000 certification at its oligonucleotide production headquarters in 2005.IDT earned its ISO 13485
ISO 13485
ISO 13485 is an ISO standard, published in 2003, that represents the requirements for a comprehensive management system for the design and manufacture of medical devices...
:2003 certification for its Quality Management System in 2008.