Ifenprodil
Encyclopedia
Ifenprodil is a selective inhibitor of the NMDA receptor
. Its effect is specific to receptors composed of the NR1 (glutamate-binding NMDA receptor subunit 1; GluN1) and NR2B (GluN2B) subunits.
NMDA receptors are multimeric ionotropic glutamate receptor
s composed of four subunits. NR1
is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.
NMDA receptor
The NMDA receptor , a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function....
. Its effect is specific to receptors composed of the NR1 (glutamate-binding NMDA receptor subunit 1; GluN1) and NR2B (GluN2B) subunits.
NMDA receptors are multimeric ionotropic glutamate receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
s composed of four subunits. NR1
GRIN1
Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.-Further reading:...
is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.