IFITM1
Encyclopedia
Interferon-induced transmembrane protein 1 is a protein
that in humans is encoded by the IFITM1 gene
. IFITM1 has also recently been designated CD225 (cluster of differentiation
225).
This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13
s (molecular weight 13.964 kDa
).
It is an intrinic membrane protein and is predicted to cross the membrane several times.
and the protein forms part of the signaling pathway.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the IFITM1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. IFITM1 has also recently been designated CD225 (cluster of differentiation
Cluster of differentiation
The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells...
225).
This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13
Molecular biology
The gene is located on the Watson (plus) strand of the short arm of chromosome 11 (11p15.5) and is 3,956 bases in length. The encoded protein has 125 amino acidAmino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
s (molecular weight 13.964 kDa
DA
DA, da, or dA may refer to:* Da , a Tony-winning play by Hugh Leonard* Da , a movie adaptation of the play by Hugh Leonard* Adi Da, a spiritual leader once known as Da Free John, and Da Love-Ananda...
).
It is an intrinic membrane protein and is predicted to cross the membrane several times.
Biochemistry
The gene is induced by interferonInterferon
Interferons are proteins made and released by host cells in response to the presence of pathogens—such as viruses, bacteria, or parasites—or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.IFNs belong to...
and the protein forms part of the signaling pathway.