Hyperplastic arteriolosclerosis
Hyperplastic arteriolosclerosis is a type of arteriolosclerosis
Arteriolosclerosis is a form of cardiovascular disease affecting the small arteries and arterioles.Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis, both associated with vessel wall thickening and luminal narrowing that may cause downstream ischemic injury...

 involving a narrowed lumen
Lumen (anatomy)
A lumen in biology is the inside space of a tubular structure, such as an artery or intestine...


The term "onion-skin" is sometimes used to describe this form of vessel with thickened concentric smooth muscle cell layer and thickened, duplicated basement membrane. In malignant hypertension these hyperplastic changes are often accompanied by fibrinoid necrosis of the arterial intima and media. These changes are most prominent in the kidney and can lead to ischemia and acute renal failure.

It can be caused by malignant hypertension
Malignant hypertension
Malignant hypertension or hypertensive emergency is severe hypertension with acute impairment of an organ system and the possibility of irreversible organ-damage...

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