Hyper-IgM syndrome type 4
Encyclopedia
Hyper-IgM syndrome type 4 is a form of Hyper IgM syndrome
which is a defect in class switch recombination downstream of the AICDA
gene that does not impair somatic hypermutation
.
Hyper IgM syndrome
Hyper IgM syndrome is a family of genetic disorders in which the level of Immunoglobulin M antibodies is relatively high. The most common type is a result of a defect in a Th2 cell protein . The disorder causes immunodeficiencies, including a higher than normal susceptibility to various types of...
which is a defect in class switch recombination downstream of the AICDA
AICDA
Activation-induced cytidine deaminase, also known as AICDA and AID, is an enzyme which in humans is encoded by the AICDA gene.- Function :This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family...
gene that does not impair somatic hypermutation
Somatic hypermutation
Somatic hypermutation is a mechanism inside cells that is part of the way the immune system adapts to the new foreign elements that confront it . SHM diversifies the receptors used by the immune system to recognize foreign elements and allows the immune system to adapt its response to new threats...
.