Howel–Evans syndrome
Encyclopedia
Howel–Evans syndrome is an extremely rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis
Hyperkeratosis
Hyperkeratosis is thickening of the stratum corneum, often associated with a qualitative abnormality of the keratin, and also usually accompanied by an increase also in the granular layer...

).

It was characterized in 1958.

A locus at 17q25 has been identified.

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