Herpes simplex virus protein vmw65
Encyclopedia
Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor) is a trans-acting
protein
that forms a complex with the host transcription factor
s Oct-1
and HCF
to induce immediate early gene transcription in the herpes simplex viruses
.
Trans-acting
In the field of molecular biology, trans-acting , in general, means "acting from a different molecule"...
protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that forms a complex with the host transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s Oct-1
Pituitary-specific positive transcription factor 1
POU domain, class 1, transcription factor 1 , also known as POU1F1, is a transcription factor for growth hormone.-Interactions:...
and HCF
Host cell factor C1
Host cell factor is a protein that in humans is encoded by the HCFC1 gene.-Interactions:Host cell factor C1 has been shown to interact with HDAC1, Histone deacetylase 2, OGT, SIN3A, SUDS3, ZBTB17, Sp1 transcription factor, MLL, PPP1CA, POU2F1, PDCD2, WDR5, CREB3 and GABPA.-Further reading:...
to induce immediate early gene transcription in the herpes simplex viruses
Herpes simplex
Herpes simplex is a viral disease caused by both Herpes simplex virus type 1 and type 2 . Infection with the herpes virus is categorized into one of several distinct disorders based on the site of infection. Oral herpes, the visible symptoms of which are colloquially called cold sores or fever...
.