Hemagglutinin-neuraminidase
Encyclopedia
Hemagglutinin-neuraminidase refers to a single viral protein
that has both hemagglutinin
and neuraminidase
activity. This is in contrast to the proteins found in influenza
, where both functions exist but in two separate proteins.
However it does show a structural similarity to influenza viral neuraminidase
and has a six-bladed beta-propeller structure.
Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses
including Mumps virus
, Human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.
Types include:
Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future.
Viral protein
A viral protein is a protein generated by a virus.Many are structural, forming the viral envelope and capsid. However, there are also viral nonstructural proteins and viral regulatory and accessory proteins.More than 490 have been identified....
that has both hemagglutinin
Hemagglutinin
Influenza hemagglutinin or haemagglutinin is a type of hemagglutinin found on the surface of the influenza viruses. It is an antigenic glycoprotein. It is responsible for binding the virus to the cell that is being infected...
and neuraminidase
Neuraminidase
Neuraminidase enzymes are glycoside hydrolase enzymes that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The most commonly known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread...
activity. This is in contrast to the proteins found in influenza
Influenza
Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae , that affects birds and mammals...
, where both functions exist but in two separate proteins.
However it does show a structural similarity to influenza viral neuraminidase
Viral neuraminidase
Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell...
and has a six-bladed beta-propeller structure.
Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses
Paramyxovirus
Paramyxoviruses are viruses of the Paramyxoviridae family of the Mononegavirales order; they are negative-sense single-stranded RNA viruses responsible for a number of human and animal diseases.-Genera:*Subfamily Paramyxovirinae**Genus Avulavirus Paramyxoviruses (from Greek para-, beyond, -myxo-,...
including Mumps virus
Mumps virus
Mumps virus is the causative agent of mumps, a well-known common childhood disease characterised by swelling of the parotid glands and other epithelial tissues, causing high morbidity and in some cases more serious complications such as deafness...
, Human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.
Types include:
- Mumps hemagglutinin-neuraminidaseMumps hemagglutinin-neuraminidaseMumps hemagglutinin-neuraminidase is a type of Hemagglutinin-neuraminidase produced by mumps....
- Parainfluenza hemagglutinin-neuraminidaseParainfluenza hemagglutinin-neuraminidaseParainfluenza hemagglutinin-neuraminidase is a type of Hemagglutinin-neuraminidase produced by Parainfluenza....
Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future.