Help Cure Muscular Dystrophy
Encyclopedia
Help Cure Muscular Dystrophy is a distributed computing
project that runs on the BOINC platform. It is a joint effort of the French
muscular dystrophy charity, L'Association française contre les myopathies; and L'Institut de biologie moléculaire et cellulaire
(Molecular and Cellular Biology Institute).
s by modelling the protein-protein interaction
s of the forty thousand relevant proteins that are listed in the Protein Data Bank
. More specifically, it models how a protein would be affected when another protein or a ligand
docks with it.
Distributed computing
Distributed computing is a field of computer science that studies distributed systems. A distributed system consists of multiple autonomous computers that communicate through a computer network. The computers interact with each other in order to achieve a common goal...
project that runs on the BOINC platform. It is a joint effort of the French
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...
muscular dystrophy charity, L'Association française contre les myopathies; and L'Institut de biologie moléculaire et cellulaire
Institut de biologie moléculaire et cellulaire
The Institut de biologie moléculaire et cellulaire is a research institute of molecular and cellular biology that is owned by the French National Centre for Scientific Research and operated by the University of Strasbourg.- External links :*...
(Molecular and Cellular Biology Institute).
Project purpose
Help Cure Muscular Dystrophy studies the function of various proteins that are produced by the two hundred genes known to be involved in the production of neuromuscular proteinProtein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
s by modelling the protein-protein interaction
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
s of the forty thousand relevant proteins that are listed in the Protein Data Bank
Protein Data Bank
The Protein Data Bank is a repository for the 3-D structural data of large biological molecules, such as proteins and nucleic acids....
. More specifically, it models how a protein would be affected when another protein or a ligand
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In a narrower sense, it is a signal triggering molecule, binding to a site on a target protein.The binding occurs by intermolecular forces, such as ionic bonds, hydrogen...
docks with it.
See also
- BOINC
- List of distributed computing projects
- Muscular dystrophyMuscular dystrophyMuscular dystrophy is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.In the 1860s, descriptions of boys who...
- World Community GridWorld Community GridWorld Community Grid is an effort to create the world's largest public computing grid to tackle scientific research projects that benefit humanity...