Harold Frost
Encyclopedia
Harold M. Frost was an US-American orthopedist and surgeon
considered to be one of the most important researchers and theorists in the field of bone
biology and bone medicine of his time. He published nearly 500 peer-reviewed scientific and
clinical articles and 16 Books and is according to the Science Citation Index
one of the most cited investigators in skeletal research.
His main academic inputs included:
Surgeon
In medicine, a surgeon is a specialist in surgery. Surgery is a broad category of invasive medical treatment that involves the cutting of a body, whether human or animal, for a specific reason such as the removal of diseased tissue or to repair a tear or breakage...
considered to be one of the most important researchers and theorists in the field of bone
Bone
Bones are rigid organs that constitute part of the endoskeleton of vertebrates. They support, and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue is a type of dense connective tissue...
biology and bone medicine of his time. He published nearly 500 peer-reviewed scientific and
clinical articles and 16 Books and is according to the Science Citation Index
Science Citation Index
The Science Citation Index is a citation index originally produced by the Institute for Scientific Information and created by Eugene Garfield in 1960, which is now owned by Thomson Reuters. The larger version covers more than 6,500 notable and significant journals, across 150 disciplines, from ...
one of the most cited investigators in skeletal research.
His main academic inputs included:
- Development of Bone Histomorphometry for description of cellular based bone formation and Bone resorptionBone resorptionBone resorption is the process by which osteoclasts break down bone and release the minerals, resulting in a transfer of calcium from bone fluid to the blood....
processes - the eleventh rip BiopsyBiopsyA biopsy is a medical test involving sampling of cells or tissues for examination. It is the medical removal of tissue from a living subject to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically...
used for diagnosis of metabolic Bone diseases - Research on the multi-cellular unit as a key to bone metabolism
- the experimental proof that EstrogenEstrogenEstrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...
reduces bone formation - the histological proof of micro-damages in human bone biopsies
- the basic model of the adaptation of the Growth plate to mechanical stress
- the Utah-Paradigm of Bone physiology (MechanostatMechanostatThe Mechanostat is a model describing bone growth and bone loss. It was promoted by Harold Frost and described extensively in the Utah Paradigm of Skeletal Physiology in the 1960’s...
-Theorem), an enhancement of Wolff's lawJulius WolffJulius Wolff was a German surgeon.-Biography:Julius Wolff was born on March 21, 1836, and received his doctorate in 1860 in the field of surgery for Bernhard von Langenbeck at the Friedrich-Wilhelms University to Berlin. In 1861 he settled down after the state examination as a general...
stating that Bone adapts to mechanical stress and that hence there is a close link between muscleMuscleMuscle is a contractile tissue of animals and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are classified as skeletal, cardiac, or smooth muscles. Their function is to...
and boneBoneBones are rigid organs that constitute part of the endoskeleton of vertebrates. They support, and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue is a type of dense connective tissue...
Books by Harold M. Frost
- Bone remodelling dynamics, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1963
- The laws of bone structure, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964
- Mathematical Elements of Lamellar Bone Remodelling, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964
- Bone biodynamics, Henry Ford Hospital international symposium, [14], Little, Brown (Boston) 1964
- The bone dynamics in osteoporosis and osteomalacia, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1966
- An introduction to biomechanics, Surgical monographs, Thomas (Springfield, Ill.), 1967, 0398028249
- Orthopaedic surgery in spasticity (Orthopaedic lectures Vol. 1), Thomas (Springfield, Ill.), 1972
- The physiology of cartilaginous, fibrous, and bony tissue (Orthopaedic lectures Vol. 2), Thomas (Springfield, Ill.), 1972, ISBN 0398025622
- Bone remodeling and its relationship to metabolic bone diseases (Orthopaedic lectures Vol. 3), Thomas (Springfield, Ill.), 1973, ISBN 0398025886
- Bone modeling and skeletal modeling errors (Orthopaedic lectures Vol. 4), Thomas (Springfield, Ill.), 1973, ISBN 039802667X
- Orthopaedic Biomechanics (Orthopaedic Lectures Vol. 5), Thomas (Springfield, Ill.), 1973, ISBN 0398028249
- Symposium on the Osteoporoses Part 1: Physioplogy, Pathophysiology, and Diagnosis, Saunders (Philadelphia), 1981
- Symposium on the Osteoporoses Part 2: Therapy and Prevention, Saunders (Philadelphia), 1981
- Intermediary organization of the skeleton, CRC Press (Boca Raton, Fla), 1986, ISBN 0849359481
- Bone in clinical orthopedics - Chapter 14: Determinants of bone strength and mass: a summary and clinical implications by Geoff Sumner-Smith, Georg Thieme Verlag, 2002, ISBN 0865778299, http://books.google.de/books?id=sKBVfDrlEyUC&pg=PR7&lpg=PR7&dq=harold+m+frost+books&source=bl&ots=BusAe6YhKi&sig=Fmv7qpB9TLoyZpBBmYE61AVb6a8&hl=de&ei=mlK_SvOIKZComgOd_9k3&sa=X&oi=book_result&ct=result&resnum=9#v=onepage&q=&f=false
- The Utah Paradigm of Skeletal Physiology Vol. 1, ISMNI
- The Utah Paradigm of Skeletal Physiology Vol. 2, ISMNI
External links
- Tribute to Harold Frost in Journal of Musculoskeletal Neuronal Interactions, 4(4), 2004, 348-356
- Harold M. Frost, M.D., D.Sc. (hon) – One man’s association in Journal of Musculoskeletal Neuronal Interactions, 6(2), 2006
- Harold M Frost William F. Neuman Awardee 2001 in Journal of Musculoskeletal Neuronal Interactions, 2(2), 2001, 117-119
- ASBMR Harold M. Frost Young Investigator Award
- ISMNI - International Society of Musculoskeletal and Neuronal Interactions
- Sun Valley Workshops - IBMS Annual Sun Valley Workshops