HSF1
Encyclopedia
Heat shock factor protein 1 is a protein
that in humans is encoded by the HSF1 gene
.
. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90
, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
and Hsp90. Upon stress, such as elevated temperature, HSF1 is released from the chaperone complex and trimerizes. HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (NGAAN). HSF1's target genes include major inducible heat shock proteins such as Hsp72
, and interestingly, noncoding RNA within Satellite III repeat regions. Its attenuation phase is initiated as a negative feedback loop with its gene product Hsp70 binding to its transactivation domain.
with NCOA6
, SYMPK
, RALBP1
, HSF2
, CEBPB
, HSPA1A
, Heat shock protein 90kDa alpha (cytosolic), member A1 and HSPA4
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the HSF1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The product of this gene is a heat-shock transcription factorTranscription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90
Hsp90
Hsp90 is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family, which is upregulated in response to stress...
, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
Mechanism of Action
HSF1 exists as an inactive monomer in a complex with Hsp40/Hsp70Hsp70
The 70 kilodalton heat shock proteins are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms...
and Hsp90. Upon stress, such as elevated temperature, HSF1 is released from the chaperone complex and trimerizes. HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (NGAAN). HSF1's target genes include major inducible heat shock proteins such as Hsp72
HSPA1A
Heat shock 70 kDa protein 1 is a protein that in humans is encoded by the HSPA1A gene.-Interactions:HSPA1A has been shown to interact with ASK1, STUB1, MSR1, BAG3, Parkin , Fanconi anemia, complementation group C, GPR37, HSF1 and AIFM1....
, and interestingly, noncoding RNA within Satellite III repeat regions. Its attenuation phase is initiated as a negative feedback loop with its gene product Hsp70 binding to its transactivation domain.
Interactions
HSF1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NCOA6
NCOA6
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
, SYMPK
SYMPK
Symplekin is a protein that in humans is encoded by the SYMPK gene.-Interactions:SYMPK has been shown to interact with CSTF2 and HSF1.-Further reading:...
, RALBP1
RALBP1
RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.-Interactions:RALBP1 has been shown to interact with RALA, REPS2, Cyclin B1, RALB and HSF1.-Further reading:...
, HSF2
HSF2
Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.-Interactions:HSF2 has been shown to interact with Nucleoporin 62 and HSF1....
, CEBPB
CEBPB
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.- Function :The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins...
, HSPA1A
HSPA1A
Heat shock 70 kDa protein 1 is a protein that in humans is encoded by the HSPA1A gene.-Interactions:HSPA1A has been shown to interact with ASK1, STUB1, MSR1, BAG3, Parkin , Fanconi anemia, complementation group C, GPR37, HSF1 and AIFM1....
, Heat shock protein 90kDa alpha (cytosolic), member A1 and HSPA4
HSPA4
Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family...
.