HMGA
Encyclopedia
HMGA is a family of high mobility group
proteins characterized by an AT-hook
. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".
A recent study has shown variations in HMGA2 to have a moderate association with adult height.
High mobility group
High-Mobility Group or HMG is a group of chromosomal proteins that help withtranscription, replication, recombination, and DNA repair.-Families:The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:...
proteins characterized by an AT-hook
AT-hook
right|thumb|The second AT-hook of [[HMGA1]] bound to the minor-groove of AT-rich DNA. The amino-acid side chains and nucleotides have been hidden....
. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".
A recent study has shown variations in HMGA2 to have a moderate association with adult height.