Ubiquitin-conjugating enzyme E2 K is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the UBE2K gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme

Ubiquitin-conjugating enzyme

Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76...

 family. It binds selectively to a large region at the N terminus of huntingtin

Huntingtin

The Huntingtin gene, also called HTT or HD gene, is the IT15 gene which codes for a protein called the huntingtin protein...

. This interaction is not influenced by the length of the huntingtin polyglutamine tract

Polyglutamine tract

A polyglutamine tract or polyQ tract is a portion of a protein consisting of a sequence of several glutamine units. A tract typically consists of about 10 to a few hundred such units....

. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis

Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...

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Interactions

HIP2 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Huntingtin

Huntingtin

The Huntingtin gene, also called HTT or HD gene, is the IT15 gene which codes for a protein called the huntingtin protein...

 and RNF2

RNF2

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.-Interactions:RNF2 has been shown to interact with TFCP2 and HIP2.-Further reading:- External links :...

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Further reading