H1299
Encyclopedia
H1299, also known as NCI
-H1299 or CRL-5803, is a human
non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.
As with other immortalized
cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53
protein which in part accounts for their proliferative
propensity. These cells have also been reported to secrete the peptide hormone neuromedin B
(NMB), but not gastrin releasing peptide
(GRP).
National Cancer Institute
The National Cancer Institute is part of the National Institutes of Health , which is one of 11 agencies that are part of the U.S. Department of Health and Human Services. The NCI coordinates the U.S...
-H1299 or CRL-5803, is a human
Human
Humans are the only living species in the Homo genus...
non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.
As with other immortalized
Biological immortality
Biological immortality refers to a stable rate of mortality as a function of chronological age. Some individual cells and entire organisms in some species achieve this state either throughout their existence or after living long enough. This requires that death occur from injury or disease rather...
cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
protein which in part accounts for their proliferative
Cell growth
The term cell growth is used in the contexts of cell development and cell division . When used in the context of cell division, it refers to growth of cell populations, where one cell grows and divides to produce two "daughter cells"...
propensity. These cells have also been reported to secrete the peptide hormone neuromedin B
Neuromedin B
Neuromedin B is a bombesin-related peptide in mammals. It was originally purified from pig spinal cord, and later shown to be present in human central nervous system and gastrointestinal tract.- Sequence :...
(NMB), but not gastrin releasing peptide
Gastrin releasing peptide
Gastrin-releasing peptide, also known as GRP, is an important regulatory molecule that has been implicated in a number of physiological and pathophysiological processes in humans....
(GRP).