Globotriaosylceramide
Encyclopedia
Globotriaosylceramide is a ganglioside
.
It is also known as "CD77". It is one of the few clusters of differentiation
that is not a protein.
It is also known as "ceramide trihexoside".
It is formed by A4GALT
.
It is metabolized by Alpha-galactosidase
.
lead to the build up of globotriaosylceramide, and this is the cause of Fabry's disease
.
Globotriaosylceramide is also the one of the targets of Shiga toxin
, which is responsible for pathogenicity of Escherichia coli
.
Ganglioside
Ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. The 60+ known gangliosides differ mainly in the position and number of NANA residues.It is a component of the cell plasma membrane that modulates cell signal transduction events...
.
It is also known as "CD77". It is one of the few clusters of differentiation
Cluster of differentiation
The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells...
that is not a protein.
It is also known as "ceramide trihexoside".
It is formed by A4GALT
A4GALT
Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.-Further reading:...
.
It is metabolized by Alpha-galactosidase
Alpha-galactosidase
Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It is encoded by the gene.- Function :...
.
Clinical significance
Defects in the enzyme alpha-galactosidaseAlpha-galactosidase
Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It is encoded by the gene.- Function :...
lead to the build up of globotriaosylceramide, and this is the cause of Fabry's disease
Fabry's disease
Fabry disease is a rare X-linked recessive lysosomal storage disease, which can cause a wide range of systemic symptoms...
.
Globotriaosylceramide is also the one of the targets of Shiga toxin
Shiga toxin
Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, whose genes are considered to be part of the genome of lambdoid prophages. The toxins are named for Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae. The most common...
, which is responsible for pathogenicity of Escherichia coli
Escherichia coli
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...
.