Germline Mosaicism
Encyclopedia
Germline mosaicism, also known as gonadal mosaicism, is a condition in which the precursor (germline
) cells to ova
and sperm
atazoa are a mixture (mosaic) of two or more genetically different cell lines.
A study of semen samples from 100 men found low-level germline mosaicism in one third of infertile men, with increased incidence with advancing paternal age
.
Germline
In biology and genetics, the germline of a mature or developing individual is the line of germ cells that have genetic material that may be passed to a child.For example, gametes such as the sperm or the egg, are part of the germline...
) cells to ova
Ovum
An ovum is a haploid female reproductive cell or gamete. Both animals and embryophytes have ova. The term ovule is used for the young ovum of an animal, as well as the plant structure that carries the female gametophyte and egg cell and develops into a seed after fertilization...
and sperm
Sperm
The term sperm is derived from the Greek word sperma and refers to the male reproductive cells. In the types of sexual reproduction known as anisogamy and oogamy, there is a marked difference in the size of the gametes with the smaller one being termed the "male" or sperm cell...
atazoa are a mixture (mosaic) of two or more genetically different cell lines.
A study of semen samples from 100 men found low-level germline mosaicism in one third of infertile men, with increased incidence with advancing paternal age
Paternal age effect
The paternal age effect can refer to the statistical relationships of: a man's age to sperm and semen abnormalities; a man's age to his fertility; a man's age to adverse pregnancy outcomes in his female partner ; a father's age at the birth of his offspring on the probability of an adverse...
.