Gephyrin is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that is a component of the postsynaptic protein network of inhibitory synapses. Positive antibody staining

Immunostaining

Immunostaining is a general term in biochemistry that applies to any use of an antibody-based method to detect a specific protein in a sample. The term immunostaining was originally used to refer to the immunohistochemical staining of tissue sections, as first described by Albert Coons in 1941...

 for gephyrin at a synapse is consistent with the presence of glycine

Glycine

Glycine is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its 'side chain', glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.Glycine is a colourless, sweet-tasting crystalline solid...

 and/or GABA-A receptors. Gephyrin displaces GABA receptors from the GABARAP

GABARAP

Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene.A study has screened 2000 participants representing more than 600 families of smokers and examined different genes showing linkage to nicotine addiction...

/P130

Nucleolar phosphoprotein p130

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.-Interactions:Nucleolar phosphoprotein p130 has been shown to interact with Coilin and CEBPB.-Further reading:...

 complex, then brings the receptors to the synapse. Once at the synapse, the protein binds to collybistin

Collybistin

Collybistin is a protein much like gephyrin which is thought to aid the formation of submembrane gephyrin aggregates that accumulate hetero-oligomeric glycine receptors. Data from Nature Neuroscience 2000 suggests that the expression of collybistin regulates the membrane disposition of gephyrin by...

 and neuroligin 2

NLGN2

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.-Further reading:...

.

The gephyrin protein is required during molybdenum cofactor

Molybdenum cofactor

Molybdenum cofactor is a cofactor required for the activity of enzymes such as sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase. It is a coordination complex formed between molybdopterin and an oxide of molybdenum.Molybdopterins, in turn, are synthesized from guanosine triphosphate...

 assembly for insertion of molybdenum

Molybdenum

Molybdenum , is a Group 6 chemical element with the symbol Mo and atomic number 42. The name is from Neo-Latin Molybdaenum, from Ancient Greek , meaning lead, itself proposed as a loanword from Anatolian Luvian and Lydian languages, since its ores were confused with lead ores...

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