Genomic phylostratigraphy
Encyclopedia
Genomic phylostratigraphy is a statistical
approach for reconstruction of macroevolutionary trends based on the principle of founder gene
formation and punctuated emergence of protein
families. Phylostratigraphy, a novel statistical method, was developed by Tomislav Domazet-Lošo
at the Ruđer Bošković Institute in Zagreb
, Croatia
. The method allows the point of origin for any existing gene to be determined by tracing the last common ancestor in which this gene existed. Based on this information, it is then possible to determine the minimal age for any given gene.
Statistics
Statistics is the study of the collection, organization, analysis, and interpretation of data. It deals with all aspects of this, including the planning of data collection in terms of the design of surveys and experiments....
approach for reconstruction of macroevolutionary trends based on the principle of founder gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
formation and punctuated emergence of protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
families. Phylostratigraphy, a novel statistical method, was developed by Tomislav Domazet-Lošo
Tomislav Domazet-Lošo
Tomislav Domazet-Lošo is a Croatian biologist. He developed genomic phylostratigraphy which enabled reconstruction of any organism evolution through development of its fetus...
at the Ruđer Bošković Institute in Zagreb
Zagreb
Zagreb is the capital and the largest city of the Republic of Croatia. It is in the northwest of the country, along the Sava river, at the southern slopes of the Medvednica mountain. Zagreb lies at an elevation of approximately above sea level. According to the last official census, Zagreb's city...
, Croatia
Croatia
Croatia , officially the Republic of Croatia , is a unitary democratic parliamentary republic in Europe at the crossroads of the Mitteleuropa, the Balkans, and the Mediterranean. Its capital and largest city is Zagreb. The country is divided into 20 counties and the city of Zagreb. Croatia covers ...
. The method allows the point of origin for any existing gene to be determined by tracing the last common ancestor in which this gene existed. Based on this information, it is then possible to determine the minimal age for any given gene.