Gene activated matrix
Encyclopedia
In gene-activated matrix technology (GAM), cytokines and growth factors could be delivered not as recomninant proteins but as plasmid
genes (Ref.1). GAM is one of the tissue engineering
approaches to wound healing. Following gene delivery
, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for prolonged period of time – leading to reproducible tissue regeneration.
Plasmid
In microbiology and genetics, a plasmid is a DNA molecule that is separate from, and can replicate independently of, the chromosomal DNA. They are double-stranded and, in many cases, circular...
genes (Ref.1). GAM is one of the tissue engineering
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions...
approaches to wound healing. Following gene delivery
Gene delivery
Gene delivery is the process of introducing foreign DNA into host cells. Gene delivery is, for example, one of the steps necessary for gene therapy and the genetic modification of crops. There are many different methods of gene delivery developed for a various types of cells and tissues, from...
, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for prolonged period of time – leading to reproducible tissue regeneration.