GM2 (ganglioside)
Encyclopedia
GM2 is a type of ganglioside
. It is associated with GM2 gangliosidoses
such as Tay-Sachs disease
.
Ganglioside
Ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. The 60+ known gangliosides differ mainly in the position and number of NANA residues.It is a component of the cell plasma membrane that modulates cell signal transduction events...
. It is associated with GM2 gangliosidoses
GM2 gangliosidoses
The GM2 gangliosidoses are a group of related genetic disorders that result from a deficiency of the enzyme beta-hexosaminidase. This enzyme catalyzes the biodegradation of fatty acid derivatives known as gangliosides. The diseases are better known by their individual names.Beta-hexosaminidase is a...
such as Tay-Sachs disease
Tay-Sachs disease
Tay–Sachs disease is an autosomal recessive genetic disorder...
.