GADD45A
Encyclopedia
Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein
that in humans is encoded by the GADD45A gene
.
with, MAP3K4
, Cdk1
, Cyclin B1
, PCNA
, GADD45GIP1
and P21
. Gadd45a has been recently shown that interacts with Aurora A kinase]].
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the GADD45A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
GADD45A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with, MAP3K4
MAP3K4
Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.-Interactions:MAP3K4 has been shown to interact with GADD45G, GADD45B and GADD45A.-Further reading:...
, Cdk1
Cdk1
Cyclin dependent kinase 1 also known as Cdk1 or cell division control protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S....
, Cyclin B1
Cyclin B1
G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.- Function :Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with to form the maturation-promoting factor...
, PCNA
PCNA
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...
, GADD45GIP1
GADD45GIP1
Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.-Interactions:GADD45GIP1 has been shown to interact with GADD45G, GADD45B and GADD45A.-Further reading:...
and P21
P21
p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 .- Function :...
. Gadd45a has been recently shown that interacts with Aurora A kinase]].