A foreign-body giant cell is a collection of fused macrophage

Macrophage

Macrophages are cells produced by the differentiation of monocytes in tissues. Human macrophages are about in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense as well as help initiate specific defense mechanisms of vertebrate animals...

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Giant cell

A giant cell is a mass formed by the union of several distinct cells . It can arise in response to an infection or foreign body.Types include:* foreign-body giant cell* Langhans giant cell* Touton giant cells...

) which are generated in response to the presence of a large foreign body

Foreign body

A foreign body is any object originating outside the body. In machinery, it can mean any unwanted intruding object.Most references to foreign bodies involve propulsion through natural orifices into hollow organs....

. This is particularly evident with implants that cause the body chronic inflammation and foreign body response.

The nuclei are arranged in a disorganized manner. This is in contrast to a Langhans giant cell

Langhans giant cell

Langhans giant cells are large cells found in granulomatous conditions.They are formed by the fusion of epithelioid cells , and contain nuclei arranged in a horseshoe-shaped pattern in the cell periphery....

, where the nuclei are arranged on the border.