Fenamic acid
Encyclopedia
Fenamic acid is a molecule which serves as a parent structure for several non-steroidal anti-inflammatory drug
s, including mefenamic acid
, tolfenamic acid
, flufenamic acid
, and meclofenamic acid
.
This compound may be synthesized by the reaction of 2-chlorobenzoic acid
and aniline
, with base and copper oxide
catalyst in the Goldberg reaction.
The self-condensation of fenamic acid yields acridone
.
Non-steroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal Anti-inflammatory medicines , are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory...
s, including mefenamic acid
Mefenamic acid
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid is marketed in the USA as Ponstel....
, tolfenamic acid
Tolfenamic acid
Tolfenamic acid is one of the class of non-steroidal anti-inflammatory drugs . It is used to treat the symptoms of migraine.- Other possible uses :...
, flufenamic acid
Flufenamic acid
Flufenamic acid, also known as Fluffy or Fluf, is a non-steroidal anti-inflammatory drug. It is pale yellow crystalline powder....
, and meclofenamic acid
Meclofenamic acid
Meclofenamic acid is a drug used for joint and muscular pain.It inhibits the synthesis of prostaglandins.No other complications-References:...
.
This compound may be synthesized by the reaction of 2-chlorobenzoic acid
2-Chlorobenzoic acid
2-Chlorobenzoic acid is a simple organic compound which can be used as a chemical building block. It may be synthesized by the oxidation of 2-chlorotoluene with potassium permanganate.It can be synthesized by diazotization. It follows Sandmeyer reaction....
and aniline
Aniline
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane...
, with base and copper oxide
Copper oxide
Copper oxide is a compound from the two elements copper and oxygen.Copper oxide may refer to:*Copper oxide , a red powder;*Copper oxide , a black powder...
catalyst in the Goldberg reaction.
The self-condensation of fenamic acid yields acridone
Acridone
Acridone is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. It may be synthesized by the self-condensation of N-phenylanthranilic acid.-Derivatives:...
.