FLNC (gene)
Encyclopedia
Filamin-C also known as actin-binding-like protein (ABPL) or filamin-2 (FLN2) is a protein
that in humans is encoded by the FLNC gene
.
genes, specifically gamma filamin. These filamin proteins crosslink actin
filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton
. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein
-binding domain.
with:
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the FLNC gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene encodes one of three related filaminFilamin
Filamins are a class of proteins that hold two actin filaments at large angles.Types include:* FLNA* FLNB* FLNC...
genes, specifically gamma filamin. These filamin proteins crosslink actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...
filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton
Cytoskeleton
The cytoskeleton is a cellular "scaffolding" or "skeleton" contained within a cell's cytoplasm and is made out of protein. The cytoskeleton is present in all cells; it was once thought to be unique to eukaryotes, but recent research has identified the prokaryotic cytoskeleton...
. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
-binding domain.
Interactions
FLNC (gene) has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with:
- INPPL1INPPL1Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.-Interactions:INPPL1 has been shown to interact with BCAR1, SORBS1, FLNC and SHC1.-Further reading:...
, - KCND2KCND2Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene. It contributes to the cardiac transient outward potassium current , the main contributing current to the repolarizing phase 1 of the cardiac action...
, - MAP2K4MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.-Interactions:MAP2K4 has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.-Further reading:...
, - MYOZ1MYOZ1Myozenin-1 is a protein that in humans is encoded by the MYOZ1 gene.-Interactions:MYOZ1 has been shown to interact with Telethonin, FLNC and Actinin, alpha 2.-Further reading:...
, - PHLDB2PHLDB2Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.-Interactions:PHLDB2 has been shown to interact with FLNC.-Further reading:...
- SGCDSGCDDelta-sarcoglycan is a protein that in humans is encoded by the SGCD gene.-Interactions:SGCD has been shown to interact with FLNC.-External links:* LOVD mutation database:...
, and - SGCGSGCGGamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene.-Interactions:SGCG has been shown to interact with FLNC.-External links:* LOVD mutation database:...
.