FANCA
Overview
 
Fanconi anemia, complementation group A, also known as FANCA, is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the FANCA gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB
FANCB
Fanconi anemia group B protein is a protein that in humans is encoded by the FANCB gene.-Further reading:...

, FANCC, FANCD1 (also called BRCA2
BRCA2
BRCA2 is a protein that in humans is encoded by the BRCA2 gene.BRCA2 orthologs have been identified in most mammals for which complete genome data are available....

), FANCD2
FANCD2
Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group currently includes FANCA, FANCB, FANCC, FANCD1 , FANCD2 , FANCE, FANCF, FANCG, and FANCL.- Function :Fanconi anemia is a genetically heterogeneous recessive disorder...

, FANCE
FANCE
Fanconi anemia group E protein is a protein that in humans is encoded by the FANCE gene.-Interactions:FANCE has been shown to interact with Fanconi anemia, complementation group C, FANCG, FANCD2, FANCF and FANCA.-Further reading:...

, FANCF
FANCF
Fanconi anemia group F protein is a protein that in humans is encoded by the FANCF gene.-Interactions:FANCF has been shown to interact with Fanconi anemia, complementation group C, FANCG, FANCA and FANCE.-Further reading:...

, FANCG
FANCG
Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.-Interactions:FANCG has been shown to interact with FANCF, FANCA, FANCE and BRCA2.-Further reading:...

, and FANCL
FANCL
E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.-Further reading:...

. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking
Crosslinking of DNA
Crosslinks in DNA occur when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand or in the opposite strands of the DNA . Crosslinks also occur between DNA and protein...

 agents, increased chromosomal breakage, and defective DNA repair.
Quotations

[When the Allied forces fire on him] Why are you always messing with me. It's got to be a joke!

[Convincing Shimizu not to kill himself] We can die here, or we can continue fighting. Which would better serve the emperor?

[Letter to his wife] We soldiers dig. We dig all day. This is the hole that we will fight and die in. Am I digging my own grave?

[About Nishi's romancing skills] There are rumors about his womanizing...But there are no women left to woo.

[In response to a soldier saying death is honorable] Kashiwara died of honorable dysentery.

There is no use for a dead soldier.

Damn this island! The Americans can have it.

Do what is right because it is right.

If you want my honest opinion, General, the best thing to do would be to sink this island to the bottom of the sea.

I'm tired of sharing this cave with all of you, I'm a one-man show from now on.

 
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