Extended physiological proprioception (EPP) is a concept pioneered by D.C. Simpson (1972) to describe the ability to perceive at the tip of the tool, in this case a prosthetic limb. The work was based on pneumatic prosthesis developed in response to disabilities incurred by infants as the result of use of the drug, thalidomide

Thalidomide

Thalidomide was introduced as a sedative drug in the late 1950s that was typically used to cure morning sickness. In 1961, it was withdrawn due to teratogenicity and neuropathy. There is now a growing clinical interest in thalidomide, and it is introduced as an immunomodulatory agent used...

, by mothers from 1957 to 1962.