Expanded Criteria Donor
Encyclopedia
Expanded Criteria Donor (ECD) is normally associated with deceased or living kidney
donors
. They are also referred to as donors with "medical complexities". According to a literature review conducted in 2006, there is very little data on the graft survival or patient survival rate of recipients who have received these organs, or the effect of specific indicators (obesity, hypertension, age, etc.) on recipient outcome. Deceased donor kidneys recovered from this pool of donors are typically related to higher risk of graft failure in transplant
. ECD donors are normally aged 60 years or older, or over 50 years with at least two of the following conditions: hypertension history, serum creatinine > 1.5 mg/dl or cause of death from cerebrovascular accident.
Of the 9319 living kidney donations reported in the American Organ Procurement and Transplantation Network (OPTN) / United Network for Organ Sharing (UNOS) database from July 2004 to December 2005, 368 (4.0%) donors were over the age
of 60 (of which 86 [0.9%] were over the age of 65), 956 (10.3%) had hypertension, 2785 (29.9%) had an eGFR <
80 mL/min per 1.73 m2 (of which 392 [4.2%] had an eGFR < 60 mL/min per 1.73 m2) and 1194 (12.8%) had a BMI
> 30 kg/m2 (of which 250 [2.7%] had a BMI > 35 kg/m2)
The concept of ECD was raised to address the discrepancy between demand and supply in kidney transplantation.
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
donors
Organ donation
Organ donation is the donation of biological tissue or an organ of the human body, from a living or dead person to a living recipient in need of a transplantation. Transplantable organs and tissues are removed in a surgical procedure following a determination, based on the donor's medical and...
. They are also referred to as donors with "medical complexities". According to a literature review conducted in 2006, there is very little data on the graft survival or patient survival rate of recipients who have received these organs, or the effect of specific indicators (obesity, hypertension, age, etc.) on recipient outcome. Deceased donor kidneys recovered from this pool of donors are typically related to higher risk of graft failure in transplant
Organ transplant
Organ transplantation is the moving of an organ from one body to another or from a donor site on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative medicine is allowing scientists and engineers to create organs to be...
. ECD donors are normally aged 60 years or older, or over 50 years with at least two of the following conditions: hypertension history, serum creatinine > 1.5 mg/dl or cause of death from cerebrovascular accident.
Of the 9319 living kidney donations reported in the American Organ Procurement and Transplantation Network (OPTN) / United Network for Organ Sharing (UNOS) database from July 2004 to December 2005, 368 (4.0%) donors were over the age
of 60 (of which 86 [0.9%] were over the age of 65), 956 (10.3%) had hypertension, 2785 (29.9%) had an eGFR <
80 mL/min per 1.73 m2 (of which 392 [4.2%] had an eGFR < 60 mL/min per 1.73 m2) and 1194 (12.8%) had a BMI
> 30 kg/m2 (of which 250 [2.7%] had a BMI > 35 kg/m2)
The concept of ECD was raised to address the discrepancy between demand and supply in kidney transplantation.
External links
- Living Donor 101: Website and organization devoted to providing information and support for living donors.