Excitatory amino acid transporter 5
Encyclopedia
Excitatory amino-acid transporter 5 (EAAT5) is a protein
that in humans is encoded by the SLC1A7 gene
.
EAAT4 is expressed predominantly in the retina
, has high affinity for the excitatory amino acid L-glutamate
. When stimulated by this amino acid, EAAT5 conducts chloride ions.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SLC1A7 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
EAAT4 is expressed predominantly in the retina
Retina
The vertebrate retina is a light-sensitive tissue lining the inner surface of the eye. The optics of the eye create an image of the visual world on the retina, which serves much the same function as the film in a camera. Light striking the retina initiates a cascade of chemical and electrical...
, has high affinity for the excitatory amino acid L-glutamate
Glutamic acid
Glutamic acid is one of the 20 proteinogenic amino acids, and its codons are GAA and GAG. It is a non-essential amino acid. The carboxylate anions and salts of glutamic acid are known as glutamates...
. When stimulated by this amino acid, EAAT5 conducts chloride ions.