Ethionamide
Encyclopedia
Ethionamide is an antibiotic
used in the treatment of tuberculosis
.
It is a prodrug
.
It has been proposed for use in combination with gatifloxacin
.
The action may be through disruption of mycolic acid
.
Chim. Fr. 1958, 687.
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
used in the treatment of tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...
.
It is a prodrug
Prodrug
A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...
.
It has been proposed for use in combination with gatifloxacin
Gatifloxacin
Gatifloxacin sold under the brand names Gatiflo, Tequin and Zymar, is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV...
.
The action may be through disruption of mycolic acid
Mycolic acid
Mycolic acids are long fatty acids found in the cell walls of the mycolata taxon, a group of bacteria that includes Mycobacterium tuberculosis, the causative agent of the disease tuberculosis. They form the major component of the cell wall of mycolata species...
.
Synthesis
Liberman, D.; Rist, N.; Grumbach, F.; Cals, S.; Moyeux, M.; Rouaix, A.; Bull. Soc.Chim. Fr. 1958, 687.