Estratest
Encyclopedia
Estratest is a hormone replacement therapy
Hormone replacement therapy (menopause)
Hormone replacement therapy is a system of medical treatment for surgically menopausal, perimenopausal and to a lesser extent postmenopausal women...

 drug that combines esterified estrogens with methyltestosterone
Methyltestosterone
Methyltestosterone is a 17-alpha-alkylated anabolic steroid used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause...

 in one pill.

Indications

Estratest is used to treat menopausal
Menopause
Menopause is a term used to describe the permanent cessation of the primary functions of the human ovaries: the ripening and release of ova and the release of hormones that cause both the creation of the uterine lining and the subsequent shedding of the uterine lining...

 women who suffer from hot flashes but do not get relief from estrogen-only therapy

History

Estratest was first marketed in the United States in 1965 by Reid-Provident Laboratories, which as 100% of Reid-Rowell, Inc. stock was acquired by the Belgian pharmaceutical company Solvay
Solvay (company)
Solvay S.A. is a Belgian chemical company with its head office in Ixelles, Brussels, Belgium. It was founded in 1863 by Ernest Solvay to produce sodium carbonate by the solvay process. Since then the company has diversified to two major sectors of activity: chemicals and plastics...

 in 1986. There has been some controversy surrounding the drug in recent years as to its status with the U.S. Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...

.

Solvay is sponsoring a clinical trial of Estratest in the United States to determine whether the product is superior to treatment with esterified estrogens tablets.

Solvay announced it has discontinued supplying Estratest and Estratest HS, and will not fill new orders after March 31, 2009.

Dosage

Estratest is sold in tablet form, with either 1.25 mg estrogens/2.5 mg methyltestosterone or 0.625 mg estrogens/1.25 mg methyltestosterone available.

Supply

Estratest was supplied by Solvay. In March 2009 Solvay announced that, based on a variety of business factors, it would discontinue supplying Estratest and Estratest HS tablets, and would stop accepting orders for the product on March 31, 2009.

External links

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