Epoxomicin
Encyclopedia
Epoxomicin is a naturally occurring selective proteasome inhibitor
with anti-inflammatory
activity. It was originally discovered in 1992. Injected, it can induce Parkinson's
-like symptoms in rats.
Derivatives of epoxomicin include carfilzomib
.
Proteasome inhibitor
Proteasome inhibitors are drugs that block the action of proteasomes, cellular complexes that break down proteins, like the p53 protein. Proteasome inhibitors are being studied in the treatment of cancer.-Examples:...
with anti-inflammatory
Anti-inflammatory
Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system....
activity. It was originally discovered in 1992. Injected, it can induce Parkinson's
Parkinson's disease
Parkinson's disease is a degenerative disorder of the central nervous system...
-like symptoms in rats.
Derivatives of epoxomicin include carfilzomib
Carfilzomib
Carfilzomib is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.-Discovery and Early Development:...
.
Further reading
- Hanada, M., et al. 1992. J. Antibiot. 45: 1746-1752. PMID: 1468981
- Meng, L., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 10403-10408. PMID: 10468620
- Schwarz, K., et al. 2000. J. Immunol. 164: 6147-6157. PMID: 10843664
- Princiotta, M.F., et al. 2001. Proc. Natl. Acad. Sci. U.S.A. 98: 513-518. PMID: 11149939
- Garrett, I.R., et al. 2003. J. Clin. Invest. 111: 1771-1782. PMID: 12782679
- McNaught, K.S., et al. 2004. Ann. Neurol. 56: 149-162. PMID: 15236415