Enzyme replacement therapy
Encyclopedia
Enzyme replacement therapy (ERT) is a medical treatment replacing an enzyme
in patients in whom that particular enzyme is deficient or absent. Usually this is done by giving the patient an intravenous (IV) infusion containing the enzyme. Enzyme replacement therapy is currently available for some lysosomal diseases: Gaucher disease, Fabry disease, MPS I, MPS VI and Glycogen storage disease type II. Enzyme replacement therapy does not "treat" the underlying disease, only the symptoms.
Leading work was done on this subject at the Department of Physiology at the University of Alberta by Mark J. Poznansky
and Damyanti Bhardwaj, where a model for enzyme therapy was developed using rats.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
in patients in whom that particular enzyme is deficient or absent. Usually this is done by giving the patient an intravenous (IV) infusion containing the enzyme. Enzyme replacement therapy is currently available for some lysosomal diseases: Gaucher disease, Fabry disease, MPS I, MPS VI and Glycogen storage disease type II. Enzyme replacement therapy does not "treat" the underlying disease, only the symptoms.
Leading work was done on this subject at the Department of Physiology at the University of Alberta by Mark J. Poznansky
Mark J. Poznansky
Dr. Mark J. Poznansky, Ph.D., O.Ont, C.M. is a research scientist and science administrator. He is the President and CEO of the Ontario Genomics Institute and was previously Chair of the Board of OGI, and the founder of G2G Consulting Inc...
and Damyanti Bhardwaj, where a model for enzyme therapy was developed using rats.