Enovid
Encyclopedia
Enovid or Enavid (in the United Kingdom
United Kingdom
The United Kingdom of Great Britain and Northern IrelandIn the United Kingdom and Dependencies, other languages have been officially recognised as legitimate autochthonous languages under the European Charter for Regional or Minority Languages...

) was the first combined oral contraceptive pill (COCP). Developed by G. D. Searle & Company
G. D. Searle & Company
G.D. Searle & Company or just Searle was a company focusing on life sciences, specifically pharmaceuticals, agriculture, and animal health. It is now part of Pfizer.- History :...

, it was first made available in the U.S. in 1957. Initially Enovid was marketed only for the treatment of menstrual disorders. On May 9, 1960 the U.S. Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...

 approved an application to market it as a contraceptive. Just a few months later, in 1961, it was approved as a contraceptive in the UK.

Enovid was discontinued in 1988, along with other first-generation high-estrogen COCPs.
Enovid consisted of 150 ug of mestranol
Mestranol
Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% ....

 and 9.58 mg of norethynodrel
Norethynodrel
Norethynodrel was the progestin used in Enovid, the first oral contraceptive....

.
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