The endomysium, meaning within the muscle, is a layer of connective tissue that ensheaths a muscle fiber and is composed mostly from reticular fibers. It also contains capillaries, nerves, and lymphatics. It overlies the muscle fiber's cell membrane: the Sarcolemma
The sarcolemma is the cell membrane of a muscle cell . It consists of a true cell membrane, called the plasma membrane, and an outer coat made up of a thin layer of polysaccharide material that contains numerous thin collagen fibrils...


The term cardiac skeleton is sometimes considered synonymous with endomysium, but sometimes cardiac skeleton refers to the combination of the endomysium and perimysium
Perimysium is a sheath of connective tissue that groups muscle fibers into bundles or fascicles.Recent advances in muscle physiology suggest that the perimysium plays a role in transmitting lateral contractile movements...


Anti-endomysial antibodies (EMA) are present in celiac disease. They do not cause any direct symptoms to muscles, but detection of EMA is useful in the diagnosis of the disease.

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