Enamelin was described in older literature as an EDTA soluble enamel protein. It accounts for the organic portion of enamel, which represents 4% of enamel's mass. It turned out in recent research to be albumin derived from blood contamination.

The current description of enamelin is a protein coded at 4q13.3 that is a modulator for mineral formation and crystal elongation in enamel. It is believed to surround the hydroxyapetite crystals in enamel.
Significant proteins in enamel are amelogenin

Amelogenin

Amelogenin is a protein found in developing tooth enamel, and it belongs to a family of extracellular matrix proteins. Developing enamel contains about 30% protein, and 90% of this is amelogenins...

s and ameloblastin

Ameloblastin

Ameloblastin, also known as amelin, is a gene-specific protein found in tooth enamel. Although less than 5% of enamel consists of protein, ameloblastins comprise 5%-10% of all enamel protein. This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis...

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