Efaproxiral
Encyclopedia
Efaproxiral is an analog of the cholesterol drug bezafibrate
developed as a radio sensitizer. It is used to increase the efficacy of certain chemotherapy
drugs which have reduced efficacy against hypoxic
(oxygen-poor) tumours, and can thus be made more effective by increasing oxygenation of the tumour tissues. However this increased oxygenation of tissues could theoretically also produce enhanced exercise capacity for 2-3 hours post intravenous infusion, which has led World Anti-Doping Agency
to categorize efaproxiral under a prohibited method to artificially enhance oxygen transfer.
Bezafibrate
Bezafibrate is a fibrate drug used for the treatment of hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.-Mode of action:...
developed as a radio sensitizer. It is used to increase the efficacy of certain chemotherapy
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
drugs which have reduced efficacy against hypoxic
Hypoxia (medical)
Hypoxia, or hypoxiation, is a pathological condition in which the body as a whole or a region of the body is deprived of adequate oxygen supply. Variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise...
(oxygen-poor) tumours, and can thus be made more effective by increasing oxygenation of the tumour tissues. However this increased oxygenation of tissues could theoretically also produce enhanced exercise capacity for 2-3 hours post intravenous infusion, which has led World Anti-Doping Agency
World Anti-Doping Agency
The World Anti-Doping Agency , , is an independent foundation created through a collective initiative led by the International Olympic Committee . It was set up on November 10, 1999 in Lausanne, Switzerland, as a result of what was called the "Declaration of Lausanne", to promote, coordinate and...
to categorize efaproxiral under a prohibited method to artificially enhance oxygen transfer.