Eamonn Healy
Encyclopedia
Dr. Eamonn F. Healy is a professor of chemistry
at St. Edward's University
in Austin, Texas
, where his research focuses on the design of structure-activity probes to elucidate enzymatic activity. Targets include HIV-1 integrase, the c-Kit and src-abl
proteins, and the metalloproteinases associated with CXCL16
shedding. He was born in New Castle West, Ireland
on September 25, 1958. He received a doctorate in chemistry in 1984 from the University of Texas at Austin
where he was a student of Dr. Michael J. S. Dewar. As a member of the Dewar research group he co-authored Austin Model 1, or AM1, a semi-empirical method for the quantum calculation of molecular electronic structure in computational chemistry
. He appears in Richard Linklater
's 2001 film Waking Life
discussing concepts similar to a technological singularity
and explaining "telescopic evolution." Dr. Healy is married to Shelley Bueche.
Eamonn F. Healy , Skylar Johnson , Charles Hauser, and Peter King “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.” FEBS Lett. 2009, 583, 2899-2906 doi:10.1016/j.febslet.2009.07.051
Eamonn F. Healy, Jonathan Sanders, Peter J. King and W. Edward Robinson, Jr “A Docking Study of L-Chicoric Acid with HIV-1 Integrase” J Mol. Graph. Model. 2009, 27 , 14. doi:10.1016/j.jmgm.2008.09.011
E. F. Healy, C. G. Wall, M.A. Fox, "Peptide Conformational Analysis using the TRIPOS Force
Field", Intl. J. Quant. Chem., 1992, 44 ,543. DOI: 10.1002/qua.560440412
R.A. Caldwell, H. Misawa, M.J.S. Dewar, E.F. Healy,"An Unusually Large Secondary Deuterium Isotope Effect", J. Am. Chem. Soc. 1987, 109, 6869. DOI: 10.1021/ja00256a061
M.J.S. Dewar, E. G. Zoebisch, E.F. Healy, J. J. P. Stewart,"AM1: A New General Purpose
Quantum Mechanical Molecular Model", J. Am. Chem. Soc. 1985, 107, 3902. DOI: 10.1021/ja00299a024
M.J.S. Dewar, , E.F. Healy, J. J. P. Stewart,"Location of Transition States in Reaction mechanisms", J. Chem. Soc., Faraday Trans. 2 1984, 80, 227.DOI: 10.1039/F29848000227
M.J.S. Dewar, , E.F. Healy, "Why Life Exists", Organometallics
1982, 1, 1705. DOI: 10.1021/om00072a029
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
at St. Edward's University
St. Edward's University
St. Edward's University is a private Roman Catholic institution of higher learning located south of Lady Bird Lake in Austin, Texas. The university offers a liberal arts education and its campus is located on a hill overlooking the city of Austin. The campus's most notable landmark is Main...
in Austin, Texas
Austin, Texas
Austin is the capital city of the U.S. state of :Texas and the seat of Travis County. Located in Central Texas on the eastern edge of the American Southwest, it is the fourth-largest city in Texas and the 14th most populous city in the United States. It was the third-fastest-growing large city in...
, where his research focuses on the design of structure-activity probes to elucidate enzymatic activity. Targets include HIV-1 integrase, the c-Kit and src-abl
ABL
ABL is a three-letter acronym that may refer to:* Abl gene, an oncogene associated with chronic myelogenous leukemia* Abetalipoproteinemia, a rare genetic disorder...
proteins, and the metalloproteinases associated with CXCL16
CXCL16
Chemokine ligand 16 is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines , CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2...
shedding. He was born in New Castle West, Ireland
Ireland
Ireland is an island to the northwest of continental Europe. It is the third-largest island in Europe and the twentieth-largest island on Earth...
on September 25, 1958. He received a doctorate in chemistry in 1984 from the University of Texas at Austin
University of Texas at Austin
The University of Texas at Austin is a state research university located in Austin, Texas, USA, and is the flagship institution of the The University of Texas System. Founded in 1883, its campus is located approximately from the Texas State Capitol in Austin...
where he was a student of Dr. Michael J. S. Dewar. As a member of the Dewar research group he co-authored Austin Model 1, or AM1, a semi-empirical method for the quantum calculation of molecular electronic structure in computational chemistry
Computational chemistry
Computational chemistry is a branch of chemistry that uses principles of computer science to assist in solving chemical problems. It uses the results of theoretical chemistry, incorporated into efficient computer programs, to calculate the structures and properties of molecules and solids...
. He appears in Richard Linklater
Richard Linklater
-Early life:Linklater was born in Houston, Texas. He studied at Sam Houston State University and left midway through his stint in college to work on an off-shore oil rig in the Gulf of Mexico. While working on the rig he read a lot of literature, but on land he developed a love of film through...
's 2001 film Waking Life
Waking Life
Waking Life is an American animated film , directed by Richard Linklater and released in 2001. The entire film was shot using digital video and then a team of artists using computers drew stylized lines and colors over each frame.The film focuses on the nature of dreams, consciousness, and...
discussing concepts similar to a technological singularity
Technological singularity
Technological singularity refers to the hypothetical future emergence of greater-than-human intelligence through technological means. Since the capabilities of such an intelligence would be difficult for an unaided human mind to comprehend, the occurrence of a technological singularity is seen as...
and explaining "telescopic evolution." Dr. Healy is married to Shelley Bueche.
Selected publications
E.F. Healy “In Defense of a Heuristic Interpretation of Quantum Mechanics”, J. Chem. Educ. 2010, 87 , 559-563. DOI: 10.1021/ed8001545Eamonn F. Healy , Skylar Johnson , Charles Hauser, and Peter King “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.” FEBS Lett. 2009, 583, 2899-2906 doi:10.1016/j.febslet.2009.07.051
Eamonn F. Healy, Jonathan Sanders, Peter J. King and W. Edward Robinson, Jr “A Docking Study of L-Chicoric Acid with HIV-1 Integrase” J Mol. Graph. Model. 2009, 27 , 14. doi:10.1016/j.jmgm.2008.09.011
E. F. Healy, C. G. Wall, M.A. Fox, "Peptide Conformational Analysis using the TRIPOS Force
Field", Intl. J. Quant. Chem., 1992, 44 ,543. DOI: 10.1002/qua.560440412
R.A. Caldwell, H. Misawa, M.J.S. Dewar, E.F. Healy,"An Unusually Large Secondary Deuterium Isotope Effect", J. Am. Chem. Soc. 1987, 109, 6869. DOI: 10.1021/ja00256a061
M.J.S. Dewar, E. G. Zoebisch, E.F. Healy, J. J. P. Stewart,"AM1: A New General Purpose
Quantum Mechanical Molecular Model", J. Am. Chem. Soc. 1985, 107, 3902. DOI: 10.1021/ja00299a024
M.J.S. Dewar, , E.F. Healy, J. J. P. Stewart,"Location of Transition States in Reaction mechanisms", J. Chem. Soc., Faraday Trans. 2 1984, 80, 227.DOI: 10.1039/F29848000227
M.J.S. Dewar, , E.F. Healy, "Why Life Exists", Organometallics
Organometallics
Organometallics is a journal published by the American Chemical Society. Its area of focus is organometallic, as well as organometalloid chemistry. This peer-reviewed journal received an Impact Factor of 3.888 as reported by the 2010 Journal Citation Reports by Thomson Reuters.The current...
1982, 1, 1705. DOI: 10.1021/om00072a029