EBV nuclear antigen 2
Encyclopedia
EBV nuclear antigen 2 is a viral protein
associated with Epstein-Barr virus
.
EBNA-2 is the main viral transactivator, switching transcription from the Wp promoters initially used after infection to the Cp promoter. Together with EBNA-3C, it also activates the LMP-1 promoter. It is known to bind the host RBP-Jκ protein that is a key player in the Notch pathway
. EBNA-2 is essential for EBV-mediated growth transformation.
Viral protein
A viral protein is a protein generated by a virus.Many are structural, forming the viral envelope and capsid. However, there are also viral nonstructural proteins and viral regulatory and accessory proteins.More than 490 have been identified....
associated with Epstein-Barr virus
Epstein-Barr virus
The Epstein–Barr virus , also called human herpesvirus 4 , is a virus of the herpes family and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis...
.
EBNA-2 is the main viral transactivator, switching transcription from the Wp promoters initially used after infection to the Cp promoter. Together with EBNA-3C, it also activates the LMP-1 promoter. It is known to bind the host RBP-Jκ protein that is a key player in the Notch pathway
Notch signaling
The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass...
. EBNA-2 is essential for EBV-mediated growth transformation.