Dystrophin-associated protein complex
Encyclopedia
The dystrophin-associated protein complex is a multiprotein complex that includes dystrophin
and the dystrophin-associated protein
s.
Many forms of muscular dystrophy
are associated with disorders of the dystrophin-associated protein complex.
Dystrophin
Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex...
and the dystrophin-associated protein
Dystrophin-associated protein
A dystrophin-associated protein is a protein that helps to form the connection between intracellular dystrophin and the extracellular basal lamina.Examples include sarcoglycan and dystroglycan....
s.
Many forms of muscular dystrophy
Muscular dystrophy
Muscular dystrophy is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.In the 1860s, descriptions of boys who...
are associated with disorders of the dystrophin-associated protein complex.