Dystrobrevin
Encyclopedia
Dystrobrevin is a protein
that binds to dystrophin
in the costamere
of skeletal muscle cells. There are at least two isoforms of dystrobrevin in man, α-dystrobrevin and β-dystrobrevin.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that binds to dystrophin
Dystrophin
Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex...
in the costamere
Costamere
The costamere is a structural-functional component of striated muscle cells which connects the sarcomere of the muscle to the cell membrane.Costameres are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils...
of skeletal muscle cells. There are at least two isoforms of dystrobrevin in man, α-dystrobrevin and β-dystrobrevin.