Science

• In geography, away from the source of a stream or river
  Source (river or stream)
  The source or headwaters of a river or stream is the place from which the water in the river or stream originates.-Definition:There is no universally agreed upon definition for determining a stream's source...
  
  
• In meteorology, away from the source of an air parcel
  Air parcel
  In fluid dynamics, within the framework of continuum mechanics, a fluid parcel is a very small amount of fluid, identifiable throughout its dynamic history while moving with the fluid flow. As it moves, the mass of a fluid parcel remains constant, while—in a compressible flow—its volume may...
  
   or mass, along the normal direction of water or air flow
• Downstream (networking), in computer or telecommunications networks
• opposite of upstream (software development)

Molecular biology

• Downstream on DNA
  Upstream and downstream (DNA)
  In molecular biology and genetics, upstream and downstream both refer to a relative position in DNA or RNA. Each strand of DNA or RNA has a 5' end and a 3' end, so named for the carbons on the deoxyribose ring. Relative to the position on the strand, downstream is the region towards the 3' end of...
  
  , determining relative positions on DNA
• Downstream in signal transduction
  Upstream and downstream (transduction)
  In molecular biology, the terms upstream and downstream can refer to the temporal and mechanistic order of cellular and molecular events. For example, in signal transduction, the second messenger acts downstream to activation of cell membrane receptors. The other way around, activation of cell...
  
  , determining temporal and mechanistic order of cellular and molecular events of signal transduction

Entertainment

• Downstream (novella) by French writer Joris-Karl Huysmans
• Downstream (album)
  Downstream (album)
  Downstream is the second studio album by the San Francisco, CA based band New Monsoon. It was recorded over a period of months from February to November in 2002 and was released in early 2003.-Track listing:# Mountai Air# Painted Moon# Downstream...
  
  , an album by New Monsoon
• "Downstream" (Land of the Lost)
  Downstream (Land of the Lost)
  "Downstream" is the fourth episode of the first season of the 1974 American television series Land of the Lost. Written by Larry Niven and directed by Dennis Steinmetz, it first aired in the United States on September 28, 1974 on NBC...
  
  , an episode of the 1974 series Land of the Lost
• Downstream (2010 film), a 2010 action science fiction film
• Downstream (1992 film), a 1992 crime film
• Downstream (song) the fourth song in the Supertramp Even in the Quietest Moments
  Even in the Quietest Moments
  Even in the Quietest Moments... is the fifth album by progressive rock band Supertramp, released in April 1977.The album was recorded mainly at Caribou Ranch Studios in Colorado with overdubs, vocals and mixing completed at The Record Plant in Los Angeles and was Supertramp's first album to use...
  
   album

Other

• Downstream (bioprocess)
  Downstream (bioprocess)
  The downstream part of a bioprocess refers to the part where the cell mass from the upstream are processed to meet purity and quality requirements. Downstream processing is usually divided into three main sections, a capture section, a purification section and a polishing section....
  
  
• Downstream (manufacturing)
  Downstream (manufacturing)
  Downstream in manufacturing refers to processes that occur later on in a production sequence or production line.Viewing a company "from order to cash" might have high-level processes such as Marketing, Sales, Order Entry, Manufacturing, Packaging, Shipping, Invoicing...
  
  
• Downstream (petroleum industry)